AM 4668 ( )
货号：
5789/50 基本售价：
11828.0 元 规格：
50 mg
产品信息
概述| 货号 | 5789/50 |
| 别名 | (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid |
性能| 供应商 | Tocris |
| 生物活性 | Potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable. |
| 运输条件 | Ambient |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 488.48 |
| 分子式 | C24H19F3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Liuet al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517. PMID: 24900872. |
