| 货号 | 14070-25mg |
| 描述 | Prostaglandin E2(PGE2) initiates its cellular effects by activating one of four E prostanoid (EP) receptors, EP1-4. ONO-8711 is a potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1, respectively, versus 67 and 76 nM for mouse EP3 and human thromboxane receptor, respectively, and >1,000 nM for other receptors).1 ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer.1,2,3 It also suppresses pain and acid-induced HCO3- secretion in the stomach.4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Watanabe, K.,Kawamori, T.,Nakatsugi, S., et al. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Research 59, 5093-5096 (1999). 2.Kawamori, T.,Uchiya, N.,Nakatsugi, S., et al. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on breast cancer development. Carcinogenesis 22(12), 2001-2004 (2001). 3.Makita, H.,Mutoh, M.,Maruyama, T., et al. A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis 28(3), 677-684 (2007). 4.Kawahara, H.,Sakamoto, A.,Takeda, S., et al. A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and C-fos gene expression in rats with chronic nerve constriction. Anesthesia and Analgesia 93, 1012-1017 (2001). 5.Omote, K.,Kawamata, T.,Nakayama, Y., et al. The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP1, ONO-8711, in a rat model of postoperative pain. Anesthesia and Analgesia 92(1), 233-238 (2001). 6.Takeuchi, K.,Aihara, E.,Sasaki, Y., et al. Involvement of cyclooxygenase-1, prostaglandin E2 and EP1 receptors in acid-induced HCO3- secretion in stomach. Journal of Physiology and Pharmacology 57(4), 661-676 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 439.2 |
| 分子式 | C22H30ClNO4S |
| CAS号 | 216158-34-8 |
| 稳定性 | ≥ 1 year |
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