RAF265
货号：
16991-50mg 基本售价：
11760.0 元 规格：
50 mg
产品信息
概述| 货号 | 16991-50mg |
| 描述 | RAF265 is a dual inhibitor of mutant B-RafV600E and vascular endothelial growth factor receptor 2 (EC50s = 0.14 and 0.19 µM, respectively, in cell-based assays).1 It can also inhibit wild-type B-Raf, platelet-derived growth factor receptor, colony-stimulating factor 1R, RET, c-KIT, SRC, and STE20 with IC50 values ranging from 20-100 nM.2 RAF265 can inhibit proliferation of melanoma and colorectal cancer cell lines with active BRAF mutations as well as suppress tumor growth in melanoma xenograft models bearing B-RafV600Emutations.2 |
| 别名 | CHIR265; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, T.,Karsy, M.,Zhuge, J., et al. B-Raf and the inhibitors: From bench to bedside. J.Hematol.Oncol. 6, 1-9 (2013).
2.Su, Y.,Vilgelm, A.E.,Kelley, M.C., et al. RAF265 inhibits the growth of advanced human melanoma tumors. Clinical Cancer Research 18(8), 2184-2198 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 518.4 |
| 分子式 | C24H16F6N6O |
| CAS号 | 927880-90-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
