4-pentynoyl-Coenzyme A (trifluoroacetate salt)
货号：
10547-10mg 基本售价：
11760.0 元 规格：
10 mg
产品信息
概述| 货号 | 10547-10mg |
| 描述 | Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins both in vivoandin vitro.1 As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. An azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.2 |
| 别名 | Click Tag™ 4-pentynoyl-CoA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yang, Y.Y.,Ascano, J.M. and Hang, H.C. Bioorthogonal chemical reporters for monitoring protein acetylation. Journal of the American Chemical Society 132, 3640-3641 (2010).
2.Kolb, H.C. and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discovery Today 8(24), 1128-1137 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 961.6 |
| 分子式 | C26H40N7O17P3S • CF3COOH |
| 稳定性 | ≥ 2 years |
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