Candesartan cilexetil
货号：
10489-10g 基本售价：
11760.0 元 规格：
10 g
产品信息
概述| 货号 | 10489-10g |
| 描述 | Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.1 Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.2 In addition to its anti-hypertensive properties, blockade of AT1 receptors with 10 mg/kg/day candesartan cilexetil in cold-restraint stressed SHR rats prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus, suggesting a therapeutic role in stress-related disorders.3 |
| 别名 | TCV-116; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baguet, J.P.,Barone-Rochette, G. and Neuder, Y. Candesartan cilexetil in the treatment of chronic heart failure. Vascular Health and Risk Management 5, 257-264 (2009).
2.Mengden, T.,Uen, S. and Bramlage, P. Management of hypertension with fixed dose combinations of candesartan cilexetil and hydrochlorothiazide: Patient perspectives and clinical utility. Vascular Health and Risk Management 5, 1043-1058 (2009).
3.Bregonzio, C.,Seltzer, A.,Armando, I., et al. Angiotensin II AT1 receptor blockade selectively enhances brain AT2 receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive rats. Stress 11(6), 457-466 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 610.7 |
| 分子式 | C33H34N6O6 |
| CAS号 | 145040-37-5 |
| 稳定性 | ≥ 2 years |
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