15-deoxy-Δ12,14-Prostaglandin J2-biotin
货号：
10141-500ug 基本售价：
11760.0 元 规格：
500 ug
产品信息
概述| 货号 | 10141-500ug |
| 描述 | 15-deoxy-Δ12,14-Prostaglandin J2(15-deoxy-Δ12,14-PGJ2; Item No. 18570) is one of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.1,2,3 The activity of the compounds in this class, which includes PGs in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G protein-coupled receptor) pathways. 15-deoxy-Δ12,14-PGJ2-biotin is an affinity probe which allows 15-deoxy-Δ12,14-PGJ2 to be detected through an interaction with the biotin ligand. 15-deoxy-Δ12,14-PGJ2-biotin was designed to allow 15-deoxy-Δ12,14-PGJ2 to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs. |
| 别名 | 15-deoxy-Δ12,14-PGJ2-biotin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Krakoff, L.R.,Vlachakis, N.,Mendlowitz, M., et al. Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high renin. Clinical Science and Molecular Medicine 48, 311s-313s (1975).
2.Kikuchi, Y.,Kita, T.,Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metastasis Reviews 13, 309-315 (1994).
3.Mueller, E.,Drori, S.,Aiyer, A., et al. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor γ isoforms. The Journal of Biological Chemisty 277(44), 41925-41930 (2002).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 626.9 |
| 分子式 | C35H54N4O4S |
| 稳定性 | ≥ 1 year |
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