CP 24,879 (hydrochloride)
货号：
10120-50mg 基本售价：
11760.0 元 规格：
50 mg
产品信息
概述| 货号 | 10120-50mg |
| 描述 | Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6desaturase.1 Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.2 |
| 别名 | p-(Isopentyloxy)-aniline; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Obukowicz, M.G.,Raz, A.,Pyla, P.D., et al. Identification and characterization of a novel Δ6/Δ5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochemical Pharmacology 55, 1045-1058 (1998).
2.Levin, G.,Duffin, K.L.,Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochemistry Journal 365, 489-496 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 215.8 |
| 分子式 | C11H17NO • HCl |
| CAS号 | 10141-51-2 |
| 稳定性 | ≥ 1 year |
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