| 货号 | 10008518-10mg |
| 描述 | 4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac (Item No. 70680).1,2,3 By inhibiting COX and subsequently suppressing PGE2 synthesis, it demonstrates anti-inflammatory and analgesic properties.4 [Bertin Catalog No. M02004] |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shimamoto, J.,Ieiri, I.,Urae, A., et al. Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele. European Journal of Clinical Pharmacology 56, 65-68 (2000). 2.Sawchuk, R.J.,Maloney, J.A.,Cartier, L.L., et al. Analysis of diclofenac and four of its metabolities in human urine by HPLC. Pharmacological Research 12, 756-762 (1995). 3.Godbillon, J.,Gauron, S. and Metayer, J.P. High-performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolities in biological fluids. Journal of Chromatography 27, 151-159 (1985). 4.Yamakazi, R.,Kawai, S.,Matsumoto, T., et al. Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells. Journal of Pharmacology and Experimental Therapeutics 289(2), 676-681 (1999). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 312.2 |
| 分子式 | C14H11Cl2NO3 |
| CAS号 | 64118-84-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |