Afatinib (maleate)
货号：
21567-5g 基本售价：
11550.0 元 规格：
5 g
产品信息
概述| 货号 | 21567-5g |
| 描述 | Afatinib (maleate) is an irreversible epidermal growth factor receptor (EGFR) and ErbB2 inhibitor (IC50s = 0.5 and 14 nM, respectively).1 Formulations containing afatinib (BIBW 2992; Item No. 11492) are used in patients with non-small cell lung carcinoma.2 Afatinib is currently in clinical trials for a variety of cancer types. |
| 别名 | Afatinib dimaleate;BIBW 2992;BIBW 2992MA2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Eskens, F.A.L.M.,Mom, C.H.,Planting, A.S.T., et al. A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. Br. J. Cancer 98(1), 80-85 (2008).
2.Wind, S.,Schnell, D.J.,Ebner, T., et al. Clinical pharmacokinetics and pharmacodynamics of afatinib. Clin. Pharmacokinet. 56(3), 232-250 (2017).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 718.1 |
| 分子式 | C24H25ClFN5O3 • 2C4H4O4 |
| CAS号 | 850140-73-7 |
| 稳定性 | ≥ 2 years |
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