| 货号 | 21523-25mg |
| 描述 | R428 is a small molecule inhibitor of Axl kinase, both in an in vitro biochemical assay and in a cell-based assay using phosphorylation of Ser473 on Akt as the readout (EC50s = 14 nM for both).1 It is orally bioavailable, blocks angiogenesis in corneal micropocket and tumor models, and reduces metastatic burden while extending survival in mouse models of breast cancer metastasis.1 R428 synergizes with cisplatin (Item No. 13119) to enhance suppression of liver micrometastasis.1 R428 is used to study the role of Axl kinase signaling in cancer, cellular senescence, and Zika virus infection.2,3,4 |
| 别名 | BGB 324; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Holland, S.J.,Pan, A.,Franci, C.R., et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 70(4), 1544-1554 (2010). 2.Brand, T.M.,Iida, M.,Stein, A.P., et al. AXL is a logical molecular target in head and neck squamous cell carcinoma. Clin. Cancer Res. 21(11), 2601-2612 (2015). 3.Jin, C.-w.,Wang, H.,Chen, Y.-q., et al. Gas6 delays senescence in vascular smooth muscle cells through the PI3K/ Akt/FoxO signaling pathway. Cell. Physiol. Biochem. 35(3), 1151-1166 (2015). 4.Meertens, L.,Labeau, A.,Dejarnac, O., et al. Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses. Cell Rep. 18(2), 324-333 (2017). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 506.6 |
| 分子式 | C30H34N8 |
| CAS号 | 1037624-75-1 |
| 稳定性 | ≥ 1 year |
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