AP-III-a4
货号：
19933-25mg 基本售价：
11550.0 元 规格：
25 mg
产品信息
概述| 货号 | 19933-25mg |
| 描述 | AP-III-a4 is a small molecule enolase inhibitor (IC50 = 0.576 µM) that inhibited cancer cell metastasis in an in vivo zebrafish cancer cell xenograft model.1 It also reduced hyperglycemia and hyperlipidemia in C57BL/Ksj-db/db mice, a transgenic model of type 2 diabetes.2 Another study found that AP-III-a4 did not directly block enolase activity in vitro and suggested the mechanism is indirect.3 |
| 别名 | ENOblock; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jung, D.-W.,Kim, W.-H.,Park, S.-H., et al. A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes. ACS Chem Biol. 8(6), 1271-1282 (2013).
2.Cho, H.,Um, J.,Lee, J.-H., et al. ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes. Sci. Rep. 7, 44186 (2017).
3.Satani, N.,Lin, Y.-H.,Hammoudi, N., et al. ENOblock does not inhibit the activity of the glycolytic enzyme enolase. PLoS One 11(12), e0168739 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 594.7 |
| 分子式 | C31H43FN8O3 |
| CAS号 | 1177827-73-4 |
| 稳定性 | ≥ 2 years |
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