SR 1824
货号：
11087-25mg 基本售价：
11494.0 元 规格：
25 mg
产品信息
概述| 货号 | 11087-25mg |
| 描述 | Peroxisome proliferator-activated receptor γ (PPARγ) is activated by the anti-diabetes drugs known as thiazolidinediones, including rosiglitazone (Item No. 71740) and pioglitazone (Item No. 71745).1 Phosphorylation of PPARγ by cyclin-dependent kinase 5 (Cdk5) causes dysregulation of genes whose expression is altered in obesity, including adiponectin.2 SR 1824 is a non-agonist PPARγ ligand (Ki = 10 nM) which blocks Cdk5-mediated phosphorylation.3 It does not inhibit activation of PPARγ by rosiglitazone (Item No. 71740).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lehmann, J.M.,Moore, L.B.,Smith-Oliver, T.A., et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956 (1995).
2.Choi, J.H.,Banks, A.S.,Estall, J.L., et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5. Nature 466, 451-456 (2010).
3.Choi, J.H.,Banks, A.S.,Kamenecka, T.M., et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature 477(7365), 477-481 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 581.5 |
| 分子式 | C33H29BrN2O3 |
| CAS号 | 1338259-06-5 |
| 稳定性 | ≥ 2 years |
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