| 货号 | 14007-25mg |
| 描述 | (+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex.1 In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.2,3,4 Aphidicolin can be used, at 3 μM, to arrest cells in G1/S phase or to increase gene amplification frequency.5,6 |
| 别名 | ICI 69653;NSC 234714; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bucknall, R.A.,Moores, H.,Simms, R., et al. Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrobial Agents and Chemotherapy 4(3), 294-298 (1973). 2.Oguro, M.,Suzuki-Hori, C.,Nagano, H., et al. The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase α. European Journal of Biochemistry 97, 603-607 (1979). 3.Krokan, H.,Wist, E. and Krokan, R.H. Aphidicolin inhibits DNA synthesis by DNA polymerase α and isolated nuclei by a similar mechanism. Nucleic Acids Research 9(18), 4709-4719 (1981). 4.Cheng, C.H. and Kuchta, R.D. DNA polymerase ε: Aphidicolin inhibition and the relationship between polymerase and exonuclease activity. Biochemistry 32, 8568-8574 (1993). 5.Kota, K.P.,Benko, J.G.,Mudhasani, R., et al. High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection. Viruses 4, 1865-1877 (2012). 6.Yin, D.X. and Schimke, R.T. Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. Proceedings of the National Academy of Sciences of the United States of America 93, 3394-3398 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 338.5 |
| 分子式 | C20H34O4 |
| CAS号 | 38966-21-1 |
| 稳定性 | ≥ 1 year |
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