| 货号 | 70770-500ug |
| 描述 | The biological effects of the cysteinyl leukotrienes (cysLTs, including LTC4, LTD4, and LTE4) are transduced mainly by a pair of 7-transmembrane receptors, CysLT1 and CysLT2.1,2,3 BAY u9773 is a non-selective antagonist of the CysLT receptors, having about the same IC50 (20-80 nM) for the inhibition of LT responses in a variety of tissue preparations containing either/or both receptors.4 In contrast, many of the commercially developed CysLT1 receptor antagonists (pranlukast or montelukast) antagonize only CysLT1 receptors. BAY u9773 is thus one of the only available tools for blocking CysLT2receptors. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lynch, K.R.,ONeill, G.P.,Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399, 789-793 (1999). 2.Heise, C.E.,ODowd, B.F.,Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536 (2000). 3.Ogasawara, H.,Ishii, S.,Yokomizo, T., et al. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2. Differential pharmacological properties and tissue distribution. The Journal of Biological Chemisty 277(21), 18763-18768 (2002). 4.Tudhope, S.R.,Cuthbert, N.J.,Abram, T.S., et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. European Journal of Pharmacology 264, 317-323 (1994). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 472.6 |
| 分子式 | C27H36O5S |
| CAS号 | 154978-38-8 |
| 稳定性 | ≥ 1 year |
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