PTC-209
货号：
16277-50mg 基本售价：
11382.0 元 规格：
50 mg
产品信息
概述| 货号 | 16277-50mg |
| 描述 | Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth.1 It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kreso, A.,van Galen, P.,Pedley, N.M., et al. Self-renewal as a therapeutic target in human colorectal cancer. Nature Medicine 20(1), 29-36 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 495.2 |
| 分子式 | C17H13Br2N5OS |
| CAS号 | 315704-66-6 |
| 稳定性 | ≥ 2 years |
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