PF 9184 ( )
货号：
5917/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 5917/50 |
| 别名 | N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
性能| 供应商 | Tocris |
| 生物活性 | Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2synthesisin vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 461.32 |
| 分子式 | C21H14Cl2N2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Mbalavieleet al (2010) Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem.Pharmacol. 79 1445. PMID: 20067770. |
