| 货号 | 5866/50 |
| 别名 | (-)-3-[3-Bromo-4-[(2,4-difluorophen |
| 供应商 | Tocris |
| 生物活性 | Potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 477.3 |
| 分子式 | C22H19BrF2N2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Selnesset al (2011) Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg.Med.Chem.Lett. 21 4066. PMID: 21641211. Hopeet al (2009) Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J.Pharmacol.Exp.Ther. 331 882. PMID: 19720877. |