| 货号 | 5311/50 |
| 别名 | 3,11-Difluoro-6,8,13-trimethylquino |
| 供应商 | Tocris |
| 生物活性 | Telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 458.48 |
| 分子式 | C22H17F2N2 |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 20 mM in DMSO |
| 参考文献 | Lagahet al (2014) RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One 9 e86187. PMID: 24454961. Phataket al (2007) Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitroandin vivo consistent with a cancer stem cell targeting mechanism. Br.J.Cancer 96 1223. PMID: 17406367. Salvatiet al (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest. 117 3236. PMID: 17932567. |