| 货号 | 1634/50 |
| 别名 | [2-[[8-(Dimethylamino)octyl]thio]-6 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 508.69 |
| 分子式 | C23H34N2OS2.C2H2O4 |
| 可溶性/溶解性 | Soluble to 15 mM in ethanol with gentle warming and to 15 mM in DMSO |
| CAS号 | 129184-48-1 |
| 参考文献 | Katoet al (1997) Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 283 328. PMID: 9336340. Nakajimaet al (1992) Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci.Lett. 141 156. PMID: 1436628. |