| 货号 | 2676/50 |
| 别名 | [6-Hydroxy-2-(4-hydroxyphenyl)benzo |
| 供应商 | Tocris |
| 生物活性 | Selective estrogen receptor modulator (SERM) that displays selectivity for ERα over ERβ(Ki values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 472.6 |
| 分子式 | C28H28N2O3S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 849662-80-2 |
| 参考文献 | Ninget al (2007) Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134). Br.J.Pharmacol. 150 19. PMID: 17115070. Yanget al (2005) Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo. Bioorg.Med.Chem.Lett. 15 1505. PMID: 15713417. |