WWL 123 (50 MG)
货号：
5317/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 5317/50 |
| 别名 | N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester |
性能| 供应商 | Tocris |
| 生物活性 | α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM). Blocks PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB1 and CB2 receptors, but is GABAA receptor dependent. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 436.5 |
| 分子式 | C28H24N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Naydenovet al (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83 361. PMID: 25033180. |
