| 货号 | 4769/50 |
| 别名 | 4-(4-Methyl-1-piperazinyl)-6-phenyl |
| 供应商 | Tocris |
| 生物活性 | Selective histamine H4 receptor agonist; displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 269.34 |
| 分子式 | C15H19N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in 2eq.HCl |
| 参考文献 | Coruzziet al (2011) Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur.J.Pharmacol. 669 121. PMID: 21839070. Altenbachet al (2008) Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands. J.Med.Chem. 51 6571. PMID: 18811133. Cowartet al (2008) Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 51 6547. PMID: 18817367. |