| 货号 | 5445/50 |
| 别名 | Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8- |
| 供应商 | Tocris |
| 生物活性 | Potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t½ = 2.6 min in human plasma). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 385.42 |
| 分子式 | C19H23N5O4< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Biffenet al (2012) Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 166 573. PMID: 22122192. Kurimotoet al (2010) Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 53 2964. PMID: 20232824. |