| 货号 | 2008/50 |
| 别名 | 6-(4-Fluorophenyl)-2,3-dihydro-5-(4 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 370.27 |
| 分子式 | C16H12FN3S.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 72873-74-6 |
| 参考文献 | Nicket al (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J.Clin.Invest. 99 975. PMID: 9062356. Leeet al (1994) A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis. Nature 372 739. PMID: 7997261. Griswoldet al (1987) SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem.Pharmacol. 36 3463. PMID: 2823821. |