| 货号 | 4766/50 |
| 别名 | 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrol |
| 供应商 | Tocris |
| 生物活性 | Potent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2,α2β4,α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 302.33 |
| 分子式 | C12H14N2.C4< |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| 参考文献 | Schneideret al (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 290 731. PMID: 10411585. Cosfordet al (1996) (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 3235. PMID: 8765504. |