| 货号 | 1255/50 |
| 别名 | (+)-cis-4,5,7a,8,9,10,11,11a-Octahy |
| 供应商 | Tocris |
| 生物活性 | Selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. Inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8. Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 344.41 |
| 分子式 | C15H20N2.C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 141474-54-6 |
| 参考文献 | Kalkmanet al (1998) Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 343 201. PMID: 9570468. Moraet al (1997) Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58 1051. PMID: 9408213. Nozulaket al (1995) (+)-cis4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity. J.Med.Chem. 38 28. PMID: 7837236. |