| 货号 | 1375/50 |
| 别名 | N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2 |
| 供应商 | Tocris |
| 生物活性 | 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A,2Band2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Orally active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 431.39 |
| 分子式 | C22H17F4N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 181629-93-6 |
| 参考文献 | Bromidgeet al (2000) Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J.Med.Chem. 43 1123. PMID: 10737744. Reavillet al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126 572. PMID: 10188965. |