| 货号 | 1374/50 |
| 别名 | 6-Chloro-2,3-dihydro-5-methyl-N-5-q |
| 供应商 | Tocris |
| 生物活性 | Potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). Increases wakefulness and motor activity in rats. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 337.81 |
| 分子式 | C19H16ClN3O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Kantoret al (2004) Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. Br.J.Pharmacol. 142 1332. PMID: 15265808. Reavillet al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126 572. PMID: 10188965. Kennettet al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603. PMID: 9886683. |