| 货号 | 1771/50 |
| 别名 | 4-Fluoro-N-[2-[4-(7-methoxy-1-napht |
| 供应商 | Tocris |
| 生物活性 | Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 443.94 |
| 分子式 | C24H26FN3O2.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 135721-98-1 |
| 参考文献 | Milliganet al (2001) S 14506: novel receptor coupling at 5-HT1A receptors. Neuropharmacology 40 334. PMID: 11166326. Limaet al (1997) Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. J.Neural Transm. 104 1059. PMID: 9503258. Colpaertet al (1992) S 14506: a novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. Drug Dev.Res. 2621. |