| 货号 | 5061/50 |
| 别名 | N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective ROCK inhibitor (IC50 values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 399.29 |
| 分子式 | C16H14N4O2 |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Piredduet al (2013) Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2) Med.Chem.Comm. 3 699. PMID: 23275831. Patelet al (2012) RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 72 5025. PMID: 22846914. |