| 货号 | 4551/50 |
| 别名 | 9-Cyclohexyl-N-[4-(4-morpholinyl)ph |
| 供应商 | Tocris |
| 生物活性 | Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 520.62 |
| 分子式 | C31H32N6O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Sinhaet al (2006) Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat.Chem.Biol. 2 29. PMID: 16408088. Wuet al (2004) Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem.Biol. 11 1229. PMID: 15380183. Wuet al (2002) A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J.Am.Chem.Soc. 124 14520. PMID: 12465946. |