| 货号 | 4525/50 |
| 别名 | 3-(Cyclopentyloxy)-N-(3,5-dichloro- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 381.25 |
| 分子式 | C18H18Cl2N2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Zhaoet al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. J.Pharmacol.Exp.Ther. 305 565. PMID: 12704225. Hatzelmann and Schudt (2001) Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J.Pharmacol.Exp.Ther. 297 267. PMID: 11259554. Raeburnet al (1994) Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. Br.J.Pharmacol. 113 1423. PMID: 7889300. |