PF 6274484 ( )
货号：
5939/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 5939/50 |
| 别名 | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide |
性能| 供应商 | Tocris |
| 生物活性 | High affinity and potent covalent EGFR kinase inhibitor (Ki = 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC50 values are 5.8 and 6.6 nM, respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 372.78 |
| 分子式 | C18H14ClFN4O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Schwartzet al (2014) Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc.Natl.Acad.Sci.U.S.A. 111 173. PMID: 24347635. |
