PF 3716556 (50 MG)
货号：
4191/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 4191/50 |
| 别名 | 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide |
性能| 供应商 | Tocris |
| 生物活性 | H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays); more potent in acidic conditions. Highly selective for H+,K+-ATPasein vitro; displays no activity at Na+,K+-ATPase. Also displays selectivity for H+,K+-ATPase over a range of 50 receptors and ion channels (IC50 > 10 μM). Inhibits gastric acid secretion in rat and dog models. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 394.47 |
| 分子式 | C22H26N4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Moriet al(2009)N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J.Pharmacol.Exp.Ther. 328 671. PMID: 18981288. |
