| 货号 | 4818/50 |
| 别名 | 1-(4-Fluorobenzoyl)-3-[[(6-methoxy- |
| 供应商 | Tocris |
| 生物活性 | Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 409.41 |
| 分子式 | C23H20FNO5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Birrellet al (2013) Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br.J.Pharmacol. 168 129. PMID: 22747912. af Forselleset al(2011)In vitroandin vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br.J.Pharmacol. 164 1847. PMID: 21595651. |