| 货号 | 1547/50 |
| 别名 | 2,3-bis[(2-Hydroxyethyl)thiol]-1,4- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 310.38 |
| 分子式 | C14H14O4S2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 93718-83-3 |
| 参考文献 | Melchheieret al (2005) Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 327 1016. PMID: 15652497. Hanet al (2004) NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 309 64. PMID: 14718602. Lazoet al (2002) Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 61 720. PMID: 11901209. |