| 货号 | 3677/50 |
| 别名 | N-[4-Methyl-9-(1-methylethyl)-9H-ca |
| 供应商 | Tocris |
| 生物活性 | Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 351.44 |
| 分子式 | C21H25N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 439861-56-0 |
| 参考文献 | Morriset al (2007) Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 25 1136. PMID: 17331209. Blocket al (2002) Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 45 3509. PMID: 12139462. Turnbullet al (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51 2441. PMID: 12145156. |