| 货号 | 1779/50 |
| 别名 | 1,2,5,6-Tetrahydro-1-[2-[[(diphenyl |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo. Also exhibits cognition-enhancing activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 386.88 |
| 分子式 | C21H22N2O3.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| CAS号 | 145645-62-1 |
| 参考文献 | O'Connellet al (2001) Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor. Eur.J.Pharmacol. 424 37. PMID: 11470258. Bordenet al (1994) Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219. PMID: 7851497. Suzdaket al (1992) NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur.J.Pharmacol. 224 189. PMID: 1468507. |