| 货号 | 2548/50 |
| 别名 | 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-be |
| 供应商 | Tocris |
| 生物活性 | High affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 1096.9 |
| 分子式 | C41H28N6Na4O17S4 |
| 可溶性/溶解性 | Soluble to 40 mM in water |
| CAS号 | 111150-22-2 |
| 参考文献 | Hausmannet al (2006) The suramin analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol.Pharmacol. 69 2058. PMID: 16551782. Kassacket al (2004) Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur.J.Med.Chem. 39 345. PMID: 15072843. Dharet al (2000) Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients. Eur.J.Cancer 36 803. PMID: 10762755. |