| 货号 | 5054/50 |
| 别名 | 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 321.37 |
| 分子式 | C19H19N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett.. PMID: 27815036. Lindgrenet al (2013) PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol. 8 1698. PMID: 23742272. |