GW 583340 dihydrochloride (50 MG)
货号：
2239/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 2239/50 |
| 别名 | N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 671.03 |
| 分子式 | C28H25ClFN5O3S2.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO with gentle warming |
| CAS号 | 388082-81-3 |
| 参考文献 | Gaulet al (2003) Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg.Med.Chem.Lett. 13 637. PMID: 12639547. |
