| 货号 | 4779/50 |
| 别名 | 2-[[3-(1,3-dioxo-1H-benz[de]isoquin |
| 供应商 | Tocris |
| 生物活性 | Selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 391.44 |
| 分子式 | C22H17NO4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Kisset al (2013) Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochim.Biophys.Acta 1831 117. PMID: 23127512. Kisset al (2012) Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol.Pharmacol. 82 1162. PMID: 22968304. |