| 货号 | 5446/50 |
| 别名 | 3-(3,4,5-Trihydroxybenzoyloxy)napht |
| 供应商 | Tocris |
| 生物活性 | FASN inhibitor. Inhibits breast cancer cell proliferation in vitro(IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 464.38 |
| 分子式 | C24H16O10 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Puiget al (2011) A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 13 R131. PMID: 22177475. Puiget al (2009) Novel inhibitors of fatty acid synthase with anticancer activity. Clin.Cancer Res. 15 7608. PMID: 20008854. |