| 货号 | 3094/50 |
| 别名 | 2-(2-Chlorophenyl)-5,7-dihydroxy-8- |
| 供应商 | Tocris |
| 生物活性 | Cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 438.3 |
| 分子式 | C21H20ClNO5.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Ambrosiniet al (2008) The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res. 68 2312. PMID: 18381438. Losiewiczet al (1994) Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem.Biophys.Res.Comm. 201589. Kauret al (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275. J.Natl.Cancer.Inst. 84 1736. PMID: 1279187. |