| 货号 | 1808/50 |
| 别名 | N-[4-[[1-[2-(6-Methyl-2-pyridinyl)e |
| 供应商 | Tocris |
| 生物活性 | Selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. Class III antiarrhythmic agent. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 474.44 |
| 分子式 | C21H27N3O3S.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| CAS号 | 113559-13-0 |
| 参考文献 | Fickeret al (2002) The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations. J.Biol.Chem. 277 4989. PMID: 11741928. Verheijcket al (1995) Effects of the delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ.Res. 76 607. PMID: 7895335. Wettweret al (1991) Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters. J.Cardiovasc.Pharmacol. 17 480. PMID: 1711611. |