DMH2 (50 MG)
货号：
5580/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 5580/50 |
| 别名 | 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
性能| 供应商 | Tocris |
| 生物活性 | Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 451.52 |
| 分子式 | C27H25N5O2 |
| 可溶性/溶解性 | Soluble to 50 mM in 2eq.HCl and to 20 mM in DMSO with gentle warming |
| 参考文献 | Tsugawaet al (2014) Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549. PMID: 25271257. |
