| 货号 | 1249/50 |
| 别名 | (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexah |
| 供应商 | Tocris |
| 生物活性 | Centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 274.36 |
| 分子式 | C19H18N2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 100999-26-6 |
| 参考文献 | Andersen and Jansen (1990) Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur.J.Pharmacol. 188 335. PMID: 1973652. Temlettet al (1989) Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 4 261. PMID: 2571082. Marksteinet al (1988) Pharmacologic properties of CY 208-243, a novel D1 agonist. Progress in Catecholamine Research. Part B. Centra 59-64. |