| 货号 | 2729/50 |
| 别名 | 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of phosphodiesterase type 4 (IC50 values are 1.9, > 100, > 100, > 100 and > 100 μM for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 316.39 |
| 分子式 | C18H24N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 135637-46-6 |
| 参考文献 | Chenget al (1997) The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice: effect of adrenalectomy. J.Pharmacol.Exp.Ther. 280 621. PMID: 9023272. Cohanet al(1996)In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633. J.Pharmacol.Exp.Ther. 278 1356. PMID: 8819523. Turneret al (1996) The in vivo pharmacology of CP-80,633, a selective inhibitor of phosphodiesterase 4. J.Pharmacol.Exp.Ther. 278 1349. PMID: 8819522. |