| 货号 | 3212/50 |
| 别名 | N-(1-Ethylpropyl)-3,6-dimethyl-2-(2 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 362.94 |
| 分子式 | C21H30N2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 175140-00-8 |
| 参考文献 | Hollensteinet al (2013) Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 499 438. PMID: 23863939. Chenet al (2008) 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J.Med.Chem. 51 1385. PMID: 18288792. |