| 货号 | 3271/50 |
| 别名 | 2-(4-Morpholinyl)-4H-pyrimido[2,1-a |
| 供应商 | Tocris |
| 生物活性 | Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 281.31 |
| 分子式 | C16H15N3O2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 168425-64-7 |
| 参考文献 | Balloet al (2007) Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)oyrimido[2,1-α]isoquinolin-4-one. J.Biol.Chem. 282 24463. PMID: 17562705. Griffenet al (2005) Selective benzopyranone and pyrimido[2,1-α]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies and radiosensitization of a human tumor cell line in vitro. J.Med.Chem. 48 569. PMID: 15658870. |